CODISIN Plus® Dihydroartemisinin - Piperaquine

Anti-Malarials

 

Drug description: 

Codisin plus is a compound product containing 40mg dihydroartemisinin and 320mg of piperaquine and necessary excipients in each tablet.

Pharmacology and indications:
Codisin plus combines the schizonticidal actions of the two drugs to produce a synergistic effect on chloroquine- resistant P. falciparum and P. vivax.

Contraindications:

  • Codisin plus is contraindicated in patients with known hypersensitivity reactions to any of the two active ingredients.
  • Patients with severe liver or kidney diseases, haematopathy (example leucopenia or thrombocytopenia), porphyria are prohibited from using Codisin plus.

Drug interaction:   Avoid concomitant administration with drugs that may increase QT interval.

Precautions:

  • Those with insufficient Liver or kidney functions should use with care.
  • Follow strictly the specified usage and dosage.
  • Contact the physician when the clinical symptoms are not significantly improved.

Use in pregnancy and lactation:
Pregnant and lactating women should take with care when administration is necessary. Doctor’s advice should be followed.
Use in the elderly:
Codisin plus should be used with care in the elderly under strict monitoring of the Doctor or Nurse.
Adverse reactions:
These include nausea, vomiting, impaired appetite, abdominal pain, diarrhea, salivation, dizziness, headache, tinnitus, skin itch and eruptions.
Dosage:
Codisin plus is taken orally after meals.
For adults: 2 tablets for the first time followed by 2 tablets at the 8th, 24th and 32nd hour.
The total dose is 8 tablets.
For children: The dosage should be decreased accordingly. Dosage adjustment is as shown in the table below
Dosage of codisin plus for different age groups


Codisin plus

Do

D1

Weight (kg)

oh

8h

24h

32h

10.19kg

1/2

½

1/2

1/2

20.19kg

1

1

1

1

30.19kg

11/2

11/2

11/2

11/2

>40kg

2

2

2

2

 

Please follow doctor’s advice

Presentation:
Codisin plus is available in pack of 9 tablets.